Source-specific host response and outcomes in critically ill patients with sepsis: a prospective cohort study.

ABSTRACT:

Purpose

There is limited knowledge on how the source of infection impacts the host response to sepsis. We aimed to compare the host response in sepsis patients with a single, known source at admission (< 24 h) to the intensive care unit.

Methods

From the molecular diagnosis and risk stratification of sepsis (MARS) prospective cohort, we measured 16 plasma host response biomarkers reflective of key host response pathways in 621 sepsis patients. In a subgroup (n = 335), blood leukocyte transcriptomes were compared between the sources. Differences in clinical patient profiles and survival were compared in the whole sepsis cohort (n = 2019).

Results

The plasma biomarker cohort was categorized into sepsis originating from the respiratory tract (n = 334, 53.8%), abdomen (n 

SUBMITTER: Peters-Sengers H 

PROVIDER: S-EPMC8667541 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature