The association between anticoagulation and adverse outcomes after a positive SARS-CoV-2 test among older outpatients: A population-based cohort study.

ABSTRACT:

Introduction

Anticoagulation may improve outcomes in patients with COVID-19 when started early in the course of illness.

Materials and methods

This was a population-based cohort study using linked administrative datasets of outpatients aged ≥65 years old testing positive for SARS-CoV-2 between January 1 and December 31, 2020 in Ontario, Canada. The key exposure was anticoagulation with warfarin or direct oral anticoagulants before COVID-19 diagnosis. We calculated propensity scores and used matching weights (MWs) to reduce baseline differences between anticoagulated and non-anticoagulated patients. The primary outcome was a composite of death or hospitalization within 60 days of a positive SARS-CoV-2 test. We used the Kaplan-Meier method and cumulative incidence functions to

SUBMITTER: Abdel-Qadir H 

PROVIDER: S-EPMC8667561 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature