CRYAB predicts clinical prognosis and is associated with immunocyte infiltration in colorectal cancer.

ABSTRACT:

Background

αB-Crystallin (CRYAB) is differentially expressed in various tumors. However, the correlation between CRYAB and immune cell infiltration in colorectal cancer (CRC) remains unclear.

Materials & methods

Kaplan-Meier survival curves in The Cancer Genome Atlas (TCGA) were used to evaluate the relationship between CRYAB expression and both overall survival and progression-free survival. The relationships between CRYAB expression and infiltrating immune cells and their corresponding gene marker sets were examined using the TIMER database.

Results

The expression of CRYAB was lower in CRC tumor tissues than in normal tissues (P < 0.05). High CRYAB gene expression and high levels of CRYAB gene methylation were correlated with high-grade malignant tumors and m

SUBMITTER: Deng J 

PROVIDER: S-EPMC8667716 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature