A transcription factor signature predicts the survival of patients with adrenocortical carcinoma.

ABSTRACT:

Background

Adrenocortical carcinoma (ACC) is a rare endocrine cancer that manifests as abdominal masses and excessive steroid hormone levels and is associated with poor clinical outcomes. Transcription factors (TFs) deregulation is found to be involved in adrenocortical tumorigenesis and cancer progression. This study aimed to construct a TF-based prognostic signature for the prediction of survival of ACC patients.

Methods

The gene expression profile and clinical information for ACC patients were downloaded from The Cancer Genome Atlas (TCGA, training set) and Gene Expression Omnibus (GEO, validation set) datasets after obtained 1,639 human TFs from a previously published study. The univariate Cox regression analysis was applied to identify the survival-related TFs and the L

SUBMITTER: Zhao J 

PROVIDER: S-EPMC8667743 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature