The influence of subventricular zone involvement in extent of resection and tumor growth pattern of glioblastoma.

ABSTRACT:

Objectives

Isocitrate dehydrogenase (IDH1/2) mutations and O6-alkylguanine DNA methyltransferase (MGMT) promoter methylations are acknowledged survival predictors in patients with glioblastoma (GB). Moreover, tumor growth patterns like multifocality and subventricular zone (SVZ) involvement seem to be associated with poorer outcomes. Here, we wanted to evaluate the influence of the SVZ involvement and the multifocal tumor growth on the extent of surgical resection and its correlation with overall survival (OS) and molecular characteristics of patients with GB.

Methods

Adult patients with primary GB who underwent surgery at our department between 2012 and 2014 were included. Preoperative magnetic resonance imaging findings were analyzed with regard

SUBMITTER: Ahmadipour Y 

PROVIDER: S-EPMC8668024 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature