Relation of cardiac function to insulin resistance as evaluated by hyperinsulinemic-euglycemic clamp analysis in individuals with type 2 diabetes.

ABSTRACT:

Aims

Whereas homeostasis model assessment of insulin resistance (HOMA-IR), an easily measured but limited index of insulin resistance, has been shown to correlate with impairment of cardiac function in individuals without diabetes, the pathological relevance of insulin resistance to the development of cardiac dysfunction in individuals with type 2 diabetes has remained unclear. Here we investigated the relation between left ventricular (LV) function as assessed by echocardiography and insulin resistance as evaluated by hyperinsulinemic-euglycemic clamp analysis, the gold standard for measurement of this parameter, in individuals with type 2 diabetes.

Methods

This retrospective study included 34 individuals with type 2 diabetes who underwent both hyperinsulinemic-euglycemic c

SUBMITTER: Otowa-Suematsu N 

PROVIDER: S-EPMC8668073 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature