Plasma heparin cofactor II activity is inversely associated with albuminuria and its annual deterioration in patients with diabetes.

ABSTRACT:

Aims/introduction

Thrombin exerts various pathophysiological functions by activating protease-activated receptors (PARs). Recent data have shown that PARs influence the development of glomerular diseases including diabetic kidney disease (DKD) by regulating inflammation. Heparin cofactor II (HCII) specifically inactivates thrombin; thus, we hypothesized that low plasma HCII activity correlates with DKD development, as represented by albuminuria.

Materials and methods

Plasma HCII activity and spot urine biomarkers, including albumin and liver-type fatty acid-binding protein (L-FABP), were determined as the urine albumin-to-creatinine ratio (uACR) and the urine L-FABP-to-creatinine ratio (uL-FABPCR) in 310 Japanese patients with diabetes mellitus (176 males and 134 females). T

SUBMITTER: Hara T 

PROVIDER: S-EPMC8668075 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature