Active Smoking Induces Aberrations in Digestive Tract Microbiota of Rats.

ABSTRACT: Cigarette smoking could have certain effects on gut microbiota. Some pioneering studies have investigated effects of active smoking on the microbiome in local segments of the digestive tract, while active smoking-induced microbiome alterations in the whole digestive tract have not been fully investigated. Here, we developed a rat model of active smoking and characterized the effects of active smoking on the microbiota within multiple regions along the digestive tract. Blood glucose and some metabolic factors levels, the microbial diversity and composition, relative abundances of taxa, bacterial network correlations and predictive functional profiles were compared between the control group and active smoking group. We found that active smoking induced hyperglycemia and significant reduction

SUBMITTER: Wang X 

PROVIDER: S-EPMC8668415 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature