Role of Borneol Induced Autophagy in Enhancing Radiosensitivity of Malignant Glioma.

ABSTRACT: Glioma is the common primary craniocerebral malignancy with unfavorable prognosis. It is currently treated by surgical resection supplemented by radiotherapy, although the resistance of glioma cells to radiation limits the therapeutic outcomes. The aim of the present study was to determine the potential radiosensitizing effects of borneol and the underlying mechanisms. We found that borneol administration along with radiotherapy significantly inhibited the growth of primary glioma cells in vitro and in vivo. Furthermore, borneol markedly increased the number of autophagosomes in the glioma cells, which coincided with increased expression of beclin-1 and LC3. And the combination of borneol and radiation exposure significantly decreased the expression levels of HIF-1α, mTORC1 a

SUBMITTER: Li Q 

PROVIDER: S-EPMC8668811 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature