Regulating Polyamine Metabolism by miRNAs in Diabetic Cardiomyopathy.

ABSTRACT:

Purpose of review

Insulin is at the heart of diabetes mellitus (DM). DM alters cardiac metabolism causing cardiomyopathy, ultimately leading to heart failure. Polyamines, organic compounds synthesized by cardiomyocytes, have an insulin-like activity and effect on glucose metabolism, making them metabolites of interest in the DM heart. This review sheds light on the disrupted microRNA network in the DM heart in relation to developing novel therapeutics targeting polyamine biosynthesis to prevent/mitigate diabetic cardiomyopathy.

Recent findings

Polyamines prevent DM-induced upregulation of glucose and ketone body levels similar to insulin. Polyamines also enhance mitochondrial respiration and thereby regulate all major metabolic pathways. Non-coding microRNAs regulate a major

SUBMITTER: Kambis TN 

PROVIDER: S-EPMC8668854 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature