Neuron-specific chromosomal megadomain organization is adaptive to recent retrotransposon expansions.

ABSTRACT: Regulatory mechanisms associated with repeat-rich sequences and chromosomal conformations in mature neurons remain unexplored. Here, we map cell-type specific chromatin domain organization in adult mouse cerebral cortex and report strong enrichment of Endogenous Retrovirus 2 (ERV2) repeat sequences in the neuron-specific heterochromatic B₂^NeuN+ megabase-scaling subcompartment. Single molecule long-read sequencing and comparative Hi-C chromosomal contact mapping in wild-derived SPRET/EiJ (Mus spretus) and laboratory inbred C57BL/6J (Mus musculus) reveal neuronal reconfigurations tracking recent ERV2 expansions in the murine germline, with significantly higher B₂^NeuN+ contact frequencies at sites with ongoing insertions in Mus musculus. Neuronal ab

SUBMITTER: Chandrasekaran S 

PROVIDER: S-EPMC8669064 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature