Dataset Information

Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis: A pilot study.

ABSTRACT:

Background

The feasibility of cognitive rehabilitation is rarely investigated in patients with advanced multiple sclerosis.

Methods

Eighteen patients with advanced multiple sclerosis (median EDSS = 7.5) were randomized into restorative or compensatory cognitive rehabilitation. Feasibility was determined by adherence rate, completion rate, patient satisfaction, self-reported fatigue, training difficulty, and training duration.

Results

Adherence rates and completion rates were over 70%, and patients were highly satisfied in both groups. Energy levels decreased minimally during the sessions (pre = 6.9 vs post = 6.4). Training difficulty (4.6) and duration (5.7) were close to ideal (scale 1-10, 5 = ideal).

Conclusions

Cognitive rehabilitation, with minor adjustments, appears feasible in patients with advanced multiple sclerosis.

SUBMITTER: Prouskas SE

PROVIDER: S-EPMC8669124 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature

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Publications

Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis: A pilot study.

Prouskas Stefanos E SE Chiaravalloti Nancy D ND Kant Neeltje N Ball Karlene K KK de Groot Vincent V Uitdehaag Bernard Mj BM Geurts Jeroen Jg JJ Kooij Elizabeth A EA Hulst Hanneke E HE

Multiple sclerosis journal - experimental, translational and clinical 20211001 4

<h4>Background</h4>The feasibility of cognitive rehabilitation is rarely investigated in patients with advanced multiple sclerosis.<h4>Methods</h4>Eighteen patients with advanced multiple sclerosis (median EDSS = 7.5) were randomized into restorative or compensatory cognitive rehabilitation. Feasibility was determined by adherence rate, completion rate, patient satisfaction, self-reported fatigue, training difficulty, and training duration.<h4>Results</h4>Adherence rates and completion rates wer ...[more]

PMID: 34917392

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Project description:BackgroundAt least 40% of individuals with multiple sclerosis (MS) exercise chronic insomnia, and the prevalence is likely higher due to underdiagnosis. Poor sleep quality has been associated with increased fatigue, anxiety, depression, and risk of relapse in individuals with MS. While cognitive behavioral therapy for insomnia (CBT-I) is the recommended treatment for chronic insomnia, the treatment effect of CBT-I in people with MS is unclear.ObjectiveThis pilot randomized control trial (RCT) assessed the feasibility and treatment effect of CBT-I to improve sleep quality and fatigue in individuals with MS with symptoms of insomnia.MethodsThirty-three individuals with MS (30 females, 3 males; 30 relapsing-remitting; 3 secondary-progressive; 53.0 ± 9.4 years old) with symptoms of insomnia were randomized into one of three arms: 1. 6-week CBT-I program, 2. 6-week active control, or 3. Single session of sleep education. Participants completed surveys to assess sleep quality, fatigue, sleep self-efficacy, depression, and anxiety.ResultsCBT-I in individuals with MS is feasible with high retention and adherence rate. All groups experienced a large magnitude of improvement in insomnia symptoms. The CBT-I and brief education groups experienced a large magnitude of improvement in sleep quality and fatigue. Only the CBT-I group demonstrated a large magnitude of improvement in sleep self-efficacy and depression.ConclusionThis is the first study to prospectively demonstrates that CBT-I is feasible in people with MS and produces promising improvements in insomnia severity, sleep quality, sleep self-efficacy and comorbid symptoms of fatigue, depression, and anxiety. Future studies are needed to determine mechanisms for these improvements and expand the scope of individuals with MS who may benefit from CBT-I. Furthermore, considering the moderate to large improvements experienced by the brief education group and the limited number of CBT-I providers, a stepped-care approach warrants consideration.

Dataset Information

Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis: A pilot study.

Background

Methods

Results

Conclusions

Publications

Feasibility of cognitive rehabilitation in patients with advanced multiple sclerosis: A pilot study.

Similar Datasets

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