In vitro activity of a novel aminomethylcycline antibacterial (KBP-7072), a third-generation tetracycline, against clinical isolates with molecularly characterized tetracycline resistance mechanisms.

ABSTRACT:

Objectives

This study evaluated the in vitro activity of KBP-7072 against 413 contemporary surveillance isolates, including subsets with known tetracycline resistance genes.

Materials

In total, 105 Klebsiella pneumoniae (51 tetracycline resistant), 103 Escherichia coli (52 tetracycline resistant), 103 Staphylococcus aureus (51 tetracycline resistant) and 102 Streptococcus pneumoniae (51 tetracycline resistant) isolates were included. These isolates were tested by broth microdilution using fresh media. CLSI/EUCAST breakpoints were applied, except for tigecycline and omadacycline, which used FDA criteria.

Results

KBP-7072 (MIC₅₀, 0.06 mg/L), tigecycline (MIC₅₀, 0.12 and 0.25 mg/L) and omadacycline (MIC₅₀

SUBMITTER: Pfaller MA 

PROVIDER: S-EPMC8669227 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature