3D printing of bioinspired compartmentalized capsular structure for controlled drug release.

ABSTRACT: Drug delivery with customized combinations of drugs, controllable drug dosage, and on-demand release kinetics is critical for personalized medicine. In this study, inspired by successive opening of layered structures and compartmentalized structures in plants, we designed a multiple compartmentalized capsular structure for controlled drug delivery. The structure was designed as a series of compartments, defined by the gradient thickness of their external walls and internal divisions. Based on the careful choice and optimization of bioinks composed of gelatin, starch, and alginate, the capsular structures were successfully manufactured by fused deposition modeling three-dimensional (3D) printing. The capsules showed fusion and firm contact between printed layers, forming complete structures

SUBMITTER: Li J 

PROVIDER: S-EPMC8669328 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature