Tcf1 Sustains the Expression of Multiple Regulators in Promoting Early Natural Killer Cell Development.

ABSTRACT: T cell factor 1 (Tcf1) is known as a critical mediator for natural killer (NK) cell development and terminal maturation. However, its essential targets and precise mechanisms involved in early NK progenitors (NKP) are not well clarified. To investigate the role of Tcf1 in NK cells at distinct developmental phases, we employed three kinds of genetic mouse models, namely, Tcf7^fl/flVav^Cre/+, Tcf7^fl/flCD122^Cre/+ and Tcf7^fl/flNcr1^Cre/+ mice, respectively. Similar to Tcf1 germline knockout mice, we found notably diminished cell number and defective development in BM NK cells from all strains. In contrast, Tcf7^fl/flNcr1^Cre/+ mice exhibited modest defects

SUBMITTER: Liu J 

PROVIDER: S-EPMC8669559 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature