Inhaled Corticosteroids Alone and in Combination With Long-Acting β2 Receptor Agonists to Treat Reduced Lung Function in Preterm-Born Children: A Randomized Clinical Trial.

ABSTRACT:

Importance

Decreases in future lung function are a hallmark of preterm birth, but studies for management of decreased lung function are limited.

Objective

To determine whether 12 weeks of treatment with inhaled corticosteroids (ICS) alone or in combination with long-acting β2 agonists (LABA) improves spirometry and exercise capacity in school-aged preterm-born children who had percent predicted forced expiratory volume in 1 second (%FEV1) less than or equal to 85% compared with inhaled placebo treatment.

Design, setting, and participants

A double-blind, randomized, placebo-controlled trial was conducted to evaluate ICS and ICS/LABA against placebo. Preterm-born children (age, 7-12 years; gestation ≤34 weeks at birth) who did not have clinically significant congenital,

SUBMITTER: Goulden N 

PROVIDER: S-EPMC8669602 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature