Association of Systolic Blood Pressure With Dementia Risk and the Role of Age, U-Shaped Associations, and Mortality.

ABSTRACT:

Importance

The optimal systolic blood pressure (SBP) to minimize the risk of dementia in older age is unknown.

Objective

To investigate whether the association between SBP and dementia risk is U-shaped and whether age and comorbidity play a role in this association.

Design, setting, and participants

This cohort study used an individual participant data approach to analyze 7 prospective, observational, population-based cohort studies that were designed to evaluate incident dementia in older adults. These studies started between 1987 and 2006 in Europe and the US. Participants had no dementia diagnosis and had SBP and/or diastolic blood pressure (BP) data at baseline and incident dementia status during follow-up. Data analysis was conducted from November 7, 2019, to Oct

SUBMITTER: van Dalen JW 

PROVIDER: S-EPMC8669604 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature