Adult allergic rhinitis sufferers have unique nasal mucosal and peripheral blood immune gene expression profiles: A case-control study.

ABSTRACT:

Background

Allergic rhinitis (AR) is a complex disease involving both mucosal and systemic immune compartments. Greater understanding of the immune networks underpinning AR pathophysiology may assist with further refining disease-specific biomarkers.

Objective

To compare immune gene expression profiles in nasal mucosa and peripheral blood samples between adults with AR and controls without AR.

Methods

This cross-sectional study included 45 adults with moderate-severe and persistent AR (37.6 ± 12.8 years; mean ± SD) and 24 adults without AR (36.6 ± 10.2). Gene expression analysis was performed using the NanoString nCounter PanCancer Immune profiling panel (n = 730 immune genes) in combination with the panel plus probe set (n = 30 allergy-related genes) with purified RN

SUBMITTER: Watts AM 

PROVIDER: S-EPMC8669689 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature