Sensory Afferent Renal Nerve Activated Gαi₂ Subunit Proteins Mediate the Natriuretic, Sympathoinhibitory and Normotensive Responses to Peripheral Sodium Challenges.

ABSTRACT: We have previously reported that brain Gαi₂ subunit proteins are required to maintain sodium homeostasis and are endogenously upregulated in the hypothalamic paraventricular nucleus (PVN) in response to increased dietary salt intake to maintain a salt resistant phenotype in rats. However, the origin of the signal that drives the endogenous activation and up-regulation of PVN Gαi₂ subunit protein signal transduction pathways is unknown. By central oligodeoxynucleotide (ODN) administration we show that the pressor responses to central acute administration and central infusion of sodium chloride occur independently of brain Gαi₂ protein pathways. In response to an acute volume expansion, we demonstrate, via the use of selective afferent renal denervation (ADNX

SUBMITTER: Moreira JD 

PROVIDER: S-EPMC8669768 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature