Ontology highlight
ABSTRACT:
SUBMITTER: Mo C
PROVIDER: S-EPMC8669774 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Mo Chen C Ye Zhenyao Z Ke Hongjie H Lu Tong T Canida Travis T Liu Song S Wu Qiong Q Zhao Zhiwei Z Ma Yizhou Y Hong L Elliot LE Kochunov Peter P Ma Tianzhou T Chen Shuo S
Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 20220101
The advent of simultaneously collected imaging-genetics data in large study cohorts provides an unprecedented opportunity to assess the causal effect of brain imaging traits on externally measured experimental results (e.g., cognitive tests) by treating genetic variants as instrumental variables. However, classic Mendelian Randomization methods are limited when handling high-throughput imaging traits as exposures to identify causal effects. We propose a new Mendelian Randomization framework to j ...[more]