Lesion covariance networks reveal proposed origins and pathways of diffuse gliomas.

ABSTRACT: Diffuse gliomas have been hypothesized to originate from neural stem cells in the subventricular zone and develop along previously healthy brain networks. Here, we evaluated these hypotheses by mapping independent sources of glioma localization and determining their relationships with neurogenic niches, genetic markers and large-scale connectivity networks. By applying independent component analysis to lesion data from 242 adult patients with high- and low-grade glioma, we identified three lesion covariance networks, which reflect clusters of frequent glioma localization. Replicability of the lesion covariance networks was assessed in an independent sample of 168 glioma patients. We related the lesion covariance networks to important clinical variables, including tumour grade and patient s

SUBMITTER: Mandal AS 

PROVIDER: S-EPMC8669792 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature