Developmental pyrethroid exposure causes long-term decreases of neuronal sodium channel expression.

ABSTRACT: Pyrethroid insecticide use has increased over recent years because of their low to moderate acute toxicity in mammals. However, there is increasing concern over the potential detrimental effects of pyrethroids on developing animals. Most recently, we have shown that developmental exposure to deltamethrin results in long-term neurobehavioral effects. Pyrethroids exert their toxicity by acting on the voltage-gated sodium channel (Na_v), delaying channel inactivation and causing hyperexcitability in the nervous system. Previous in vitro studies found that exposure to agents that increase Na⁺ influx, including deltamethrin decreased Na_v mRNA expression. However, it is unknown whether this occurs in vivo. To determine whether developmental pyrethroid exposure dec

SUBMITTER: Magby JP 

PROVIDER: S-EPMC8669832 | biostudies-literature | 2017 May

REPOSITORIES: biostudies-literature