Clinical and genomic signatures of rising SARS-CoV-2 Delta breakthrough infections in New York.

ABSTRACT: In 2021, Delta has become the predominant SARS-CoV-2 variant worldwide. While vaccines effectively prevent COVID-19 hospitalization and death, vaccine breakthrough infections increasingly occur. The precise role of clinical and genomic determinants in Delta infections is not known, and whether they contribute to increased rates of breakthrough infections compared to unvaccinated controls. Here, we show a steep and near complete replacement of circulating variants with Delta between May and August 2021 in metropolitan New York. We observed an increase of the Delta sublineage AY.25, its spike mutation S112L, and nsp12 mutation F192V in breakthroughs. Delta infections were associated with younger age and lower hospitalization rates than Alpha. Delta breakthroughs increased significantly with

SUBMITTER: Duerr R 

PROVIDER: S-EPMC8669846 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature