The rise and spread of the SARS-CoV-2 AY.122 lineage in Russia.

ABSTRACT:

Background

Delta has outcompeted most preexisting variants of SARS-CoV-2, becoming the globally predominant lineage by mid-2021. Its subsequent evolution has led to emergence of multiple sublineages, many of which are well-mixed between countries.

Aim

Here, we aim to study the emergence and spread of the Delta lineage in Russia.

Methods

We use a phylogeographic approach to infer imports of Delta sublineages into Russia, and phylodynamic models to assess the rate of their spread.

Results

We show that nearly the entire Delta epidemic in Russia has probably descended from a single import event despite genetic evidence of multiple Delta imports. Indeed, over 90% of Delta samples in Russia are characterized by the nsp2:K81N+ORF7a:P45L pair of mutations which is rare

SUBMITTER: Klink GV 

PROVIDER: S-EPMC8669866 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature