Comprehensive analysis of pyroptosis regulators and tumor immune microenvironment in clear cell renal cell carcinoma.

ABSTRACT:

Background

Increasing evidence has indicated that pyroptosis could regulate the tumor immune microenvironment (TIME) to affect the tumor development. As a highly immunogenic tumor, clear cell renal cell carcinoma (ccRCC) can benefit from immunotherapy, but related research on pyroptosis in the TIME of ccRCC is still deficient.

Methods

Available data derived from TCGA and GEO databases were analyzed to identify the different expression profiles of pyroptosis in ccRCC and normal tissues, and the correlation of pyroptosis regulators with TIME was evaluated in ccRCC.

Results

According to consensus clustering analysis, two differential expression levels of subtypes were identified to affect patient prognosis, and were related to histological tumor stage and grade. Immune c

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC8670029 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature