Computational modelling of chromosomally clustering protein domains in bacteria.

ABSTRACT:

Background

In bacteria, genes with related functions-such as those involved in the metabolism of the same compound or in infection processes-are often physically close on the genome and form groups called clusters. The enrichment of such clusters over various distantly related bacteria can be used to predict the roles of genes of unknown function that cluster with characterised genes. There is no obvious rule to define a cluster, given their variability in size and intergenic distances, and the definition of what comprises a "gene", since genes can gain and lose domains over time. Protein domains can cluster within a gene, or in adjacent genes of related function, and in both cases these are chromosomally clustered. Here, we model the distances between pairs of protein domain codin

SUBMITTER: Cotroneo CE 

PROVIDER: S-EPMC8670047 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature