Identification and validation of a regulatory mutation upstream of the BMP2 gene associated with carcass length in pigs.

ABSTRACT:

Background

Carcass length is very important for body size and meat production for swine, thus understanding the genetic mechanisms that underly this trait is of great significance in genetic improvement programs for pigs. Although many quantitative trait loci (QTL) have been detected in pigs, very few have been fine-mapped to the level of the causal mutations. The aim of this study was to identify potential causal single nucleotide polymorphisms (SNPs) for carcass length by integrating a genome-wide association study (GWAS) and functional assays.

Results

Here, we present a GWAS in a commercial Duroc × (Landrace × Yorkshire) (DLY) population that reveals a prominent association signal (P = 4.49E-07) on pig chromosome 17 for carcass length, which was further validated in two o

SUBMITTER: Li J 

PROVIDER: S-EPMC8670072 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature