Leukocyte telomere length and amyotrophic lateral sclerosis: a Mendelian randomization study.

ABSTRACT:

Background

Observational studies have suggested that telomere length is associated with amyotrophic lateral sclerosis (ALS). However, whether this association is causal remains unclear. In this study, we aimed to explore the causal relationship between leukocyte telomere length (LTL) and ALS by a two-sample Mendelian randomization (MR) approach. Single-nucleotide polymorphisms (SNPs) for LTL were identified through high-quality genome-wide association studies (GWASs). The ALS GWAS summary data (20,806 cases; 59,804 controls) with largest sample size to date was obtained. We adopted the inverse variance weighted (IVW) method to examine the effect of LTL on ALS and used the weighted median method, simple median method, MR Egger method and MR-PRESSO method to perform sensitivity analy

SUBMITTER: Xia K 

PROVIDER: S-EPMC8670150 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature