Topical corticosteroid for treatment of hand osteoarthritis: study protocol for a randomised controlled trial.

ABSTRACT: BACKGROUND:Hand osteoarthritis is a common and disabling chronic joint disease with a lack of effective therapies. Emerging evidence suggests the role of local inflammation in causing pain in hand osteoarthritis. Corticosteroids are potent anti-inflammatory drugs used in many rheumatic diseases. The aim of this randomised, double-blind, placebo-controlled trial is to determine whether topical corticosteroid reduces pain over 6 weeks in patients with hand osteoarthritis. METHODS:One hundred participants with hand osteoarthritis will be recruited from the community in Melbourne, Australia, and randomly allocated in a 1:1 ratio to receive either topical Diprosone OV or placebo ointment administered 3 times daily on the painful hand joints for 6 weeks. The primary outcome is pain reduction (as

SUBMITTER: Wang Y 

PROVIDER: S-EPMC8670184 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature