Biodegradable reduce expenditure bioreactor for augmented sonodynamic therapy via regulating tumor hypoxia and inducing pro-death autophagy.

ABSTRACT:

Backgrounds

Sonodynamic therapy (SDT) as an emerging reactive oxygen species (ROS)-mediated antitumor strategy is challenged by the rapid depletion of oxygen, as well as the hypoxic tumor microenvironment. Instead of the presently available coping strategies that amplify the endogenous O₂ level, we have proposed a biodegradable O₂ economizer to reduce expenditure for augmenting SDT efficacy in the present study.

Results

We successfully fabricated the O₂ economizer (HMME@HMONs-3BP-PEG, HHBP) via conjugation of respiration inhibitor 3-bromopyruvate (3BP) with hollow mesoporous organosilica nanoparticles (HMONs), followed by the loading of organic sonosensitizers (hematoporphyrin monomethyl ether; HMME) and further surface modification of poly(e

SUBMITTER: Zou W 

PROVIDER: S-EPMC8670251 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature