Tetrandrine alleviates podocyte injury via calcium-dependent calpain-1 signaling blockade.

ABSTRACT:

Background

Podocytes have become a crucial target for interventions in proteinuric kidney diseases. Many studies have reported that overexpression of transient receptor potential cation channel protein 6 (TRPC6) in podocyte injury upregulates intracellular Ca²⁺ influx and stimulates Ca²⁺-dependent protease calpain-1 signaling. The traditional Chinese drug, tetrandrine, a nonselective Ca²⁺ channel blocker, has long been used to treat chronic kidney disease. This research aimed to explore the possible mechanisms underlying the anti-proteinuric properties of tetrandrine.

Methods

We investigated the involvement of tetrandrine in Ca²⁺ dependent calpain-1 signaling in mouse podocytes and adriamycin-induced nephropathy rats. Cyclosporine

SUBMITTER: Ding Y 

PROVIDER: S-EPMC8670271 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature