Longitudinal DNA methylation dynamics as a practical indicator in clinical epigenetics.

ABSTRACT:

Background

One of the fundamental assumptions of DNA methylation in clinical epigenetics is that DNA methylation status can change over time with or without interplay with environmental and clinical conditions. However, little is known about how DNA methylation status changes over time under ordinary environmental and clinical conditions. In this study, we revisited the high frequency longitudinal DNA methylation data of two Japanese males (24 time-points within three months) and characterized the longitudinal dynamics.

Results

The results showed that the majority of CpGs on Illumina HumanMethylation450 BeadChip probe set were longitudinally stable over the time period of three months. Focusing on dynamic and stable CpGs extracted from datasets, dynamic CpGs were more likely

SUBMITTER: Komaki S 

PROVIDER: S-EPMC8670275 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature