The gut microbiota in pediatric multiple sclerosis and demyelinating syndromes.

ABSTRACT:

Objective

To examine the gut microbiota in individuals with and without pediatric-onset multiple sclerosis (MS).

Methods

We compared stool-derived microbiota of Canadian Pediatric Demyelinating Disease Network study participants ≤21 years old, with MS (disease-modifying drug [DMD] exposed and naïve) or monophasic acquired demyelinating syndrome [monoADS] (symptom onset <18 years), and unaffected controls. All were ≥30 days without antibiotics or corticosteroids. V4 region 16S RNA gene-derived amplicon sequence variants (Illumina MiSeq) were assessed using negative binomial regression and network analyses; rate ratios were age- and sex-adjusted (aRR).

Results

Thirty-two MS, 41 monoADS (symptom onset [mean] = 14.0 and 6.9 years) and 36 control participants were included

SUBMITTER: Tremlett H 

PROVIDER: S-EPMC8670321 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature