Impact of T cells on neurodegeneration in anti-GAD65 limbic encephalitis.

ABSTRACT:

Objective

Direct pathogenic effects of autoantibodies to the 65 kDa isoform of glutamic acid decarboxylase (GAD65) in autoimmune limbic encephalitis (LE) have been questioned due to its intracellular localization. We therefore hypothesized a pathogenic role for T cells.

Methods

We assessed magnet resonance imaging, neuropsychological and peripheral blood, and CSF flow cytometry data of 10 patients with long-standing GAD65-LE compared to controls in a cross-sectional manner. These data were related to each other within the GAD65-LE group and linked to neuropathological findings in selective hippocampectomy specimen from another two patients. In addition, full-resolution human leukocyte antigen (HLA) genotyping of all patients was performed.

Results

Compared to controls

SUBMITTER: Dik A 

PROVIDER: S-EPMC8670322 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature