Enhancing Microbiome Research through Genome-Scale Metabolic Modeling.
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ABSTRACT:
SUBMITTER: Ankrah NYD
PROVIDER: S-EPMC8670372 | biostudies-literature | 2021 Dec
REPOSITORIES: biostudies-literature
Publications
Enhancing Microbiome Research through Genome-Scale Metabolic Modeling.
Ankrah Nana Y D NYD Bernstein David B DB Biggs Matthew M Carey Maureen M Engevik Melinda M García-Jiménez Beatriz B Lakshmanan Meiyappan M Pacheco Alan R AR Sulheim Snorre S Medlock Gregory L GL
mSystems 20211214 6
Construction and analysis of genome-scale metabolic models (GEMs) is a well-established systems biology approach that can be used to predict metabolic and growth phenotypes. The ability of GEMs to produce mechanistic insight into microbial ecological processes makes them appealing tools that can open a range of exciting opportunities in microbiome research. Here, we briefly outline these opportunities, present current rate-limiting challenges for the trustworthy application of GEMs to microbiome ...[more]
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