Comprehensive Analysis of m⁶A Regulators Characterized by the Immune Cell Infiltration in Head and Neck Squamous Cell Carcinoma to Aid Immunotherapy and Chemotherapy.

ABSTRACT:

Background

N6-Methyladenosine (m⁶A), which is a prevalent regulator of mRNA expression, has gathered increasing study interests. Though the role of m⁶A as being important in many biological processes (such as growth and proliferation of cancers) has been well documented, its potential role in tumor immune microenvironment (TIME) has rarely been analyzed.

Methods

We downloaded RNA expression, single nucleotide polymorphism (SNP), and copy number variation (CNV) data from The Cancer Genome Atlas (TCGA). We then curated 21 m⁶A regulators and clustered patients into three m⁶A subtypes and m⁶A-related gene subtypes and compared them based on overall survival (OS). The combination of CIBERSORT as well as ssGSEA quantified the

SUBMITTER: Yang Z 

PROVIDER: S-EPMC8670405 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature