Olfactory cleft mucus proteome in chronic rhinosinusitis: a case-control pilot study.

ABSTRACT:

Background

Mechanisms of smell loss in chronic rhinosinusitis (CRS) are still unclear and likely multifactorial. Little attention has been given to olfactory cleft (OC) mucus proteins involved in odorant binding and metabolizing enzymes and their potential role in smell loss.

Methods

Mucus from the OC was sampled from patients with CRS (n = 20) and controls (n = 10). Liquid chromatography and mass spectrometry were performed, followed by data processing so that protein groups could be identified, quantified, and compared. Hierarchical clustering and bioinformatic analysis were performed on significantly different proteins to explore for enrichment in known biologic pathways.

Results

A total of 2514 proteins were found in OC mucus from all 30 subjects. Significant diff

SUBMITTER: Soler ZM 

PROVIDER: S-EPMC8670410 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature