Methods for improving the immunogenicity and efficacy of cancer vaccines.

ABSTRACT:

Introduction

Cancer vaccines represent one of the oldest immunotherapy strategies. A variety of tumor-associated antigens have been exploited to investigate their immunogenicity as well as multiple strategies for vaccine administration. These efforts have led to the development of several clinical trials in tumors with different histological origins to test the clinical efficacy of cancer vaccines. However, suboptimal clinical results have been reported mainly due to the lack of optimized strategies to induce strong and sustained systemic tumor antigen-specific immune responses.

Areas covered

We provide an overview of different types of cancer vaccines that have been developed and used in the context of clinical studies. Moreover, we review different preclinical and clinical

SUBMITTER: Pilla L 

PROVIDER: S-EPMC8670419 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature