Computational Assessment of Hemodynamics Vortices Within the Cerebral Vasculature Using Informational Entropy.

ABSTRACT: Propper assessment of hemodynamic swirling flow patterns, vortices, may help understand the influence of disturbed flow on arterial wall pathophysiology and remodeling. Studies have shown that vortices trigger pathologic cellular changes within the vasculature such as increased inflammation and cellular apoptosis, leading to weakening of the vessel wall indicative of aneurysm development and rupture. Yet many studies qualitatively assess the presence of vortices within the vasculature or assess only their centermost region (critical point analysis) which overlooks the broader characteristics of flow, leading to a narrow view of vortices. This chapter provides a protocol for utilizing commercially available computational fluid dynamic software (ANSYS-FLUENT) to simulate realistic hemodynami

SUBMITTER: Sunderland K 

PROVIDER: S-EPMC8670422 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature