Vessel length on SNAP MRA and TOF MRA is a potential imaging biomarker for brain blood flow.

ABSTRACT:

Purpose

To explore feasibility of using the vessel length on time-of-flight (TOF) or simultaneous non-contrast angiography and intraplaque hemorrhage (SNAP) MRA as an imaging biomarker for brain blood flow, by using arterial spin labeling (ASL) perfusion imaging and 3D phase contrast (PC) quantitative flow imaging as references.

Methods

In a population of thirty subjects with carotid atherosclerotic disease, the visible intracranial arteries on TOF and SNAP were semi-automatically traced and the total length of the distal segments was calculated with a dedicated software named iCafe. ASL blood flow was calculated automatically using the recommended hemodynamic model. PC blood flow was obtained by generating cross-sectional arterial images and semi-automatically drawing the l

SUBMITTER: Gould A 

PROVIDER: S-EPMC8670530 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature