A comparison of host response strategies to distinguish bacterial and viral infection.

ABSTRACT:

Objectives

Compare three host response strategies to distinguish bacterial and viral etiologies of acute respiratory illness (ARI).

Methods

In this observational cohort study, procalcitonin, a 3-protein panel (CRP, IP-10, TRAIL), and a host gene expression mRNA panel were measured in 286 subjects with ARI from four emergency departments. Multinomial logistic regression and leave-one-out cross validation were used to evaluate the protein and mRNA tests.

Results

The mRNA panel performed better than alternative strategies to identify bacterial infection: AUC 0.93 vs. 0.83 for the protein panel and 0.84 for procalcitonin (P<0.02 for each comparison). This corresponded to a sensitivity and specificity of 92% and 83% for the mRNA panel, 81% and 73% for the protein panel, an

SUBMITTER: Ross M 

PROVIDER: S-EPMC8670660 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature