Effective connectivity in subcortical visual structures in de novo Patients with Parkinson's Disease.

ABSTRACT:

Background

Parkinson's disease (PD) manifests with the appearance of non-motor symptoms before motor symptoms onset. Among these, dysfunctioning visual structures have recently been reported to occur at early disease stages.

Objective

This study addresses effective connectivity in the visual network of PD patients.

Methods

Using functional MRI and dynamic causal modeling analysis, we evaluated the connectivity between the superior colliculus, the lateral geniculate nucleus and the primary visual area V1 in de novo untreated PD patients (n = 22). A subset of the PD patients (n = 8) was longitudinally assessed two times at two months and at six months after starting dopaminergic treatment. Results were compared to those of age-matched healthy controls (n = 22).

Resul

SUBMITTER: Bellot E 

PROVIDER: S-EPMC8670854 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature