The Selective Loss of Purkinje Cells Induces Specific Peripheral Immune Alterations.

ABSTRACT: The progression of neurodegenerative diseases is reciprocally associated with impairments in peripheral immune responses. We investigated different contexts of selective neurodegeneration to identify specific alterations of peripheral immune cells and, at the same time, discover potential biomarkers associated to this pathological condition. Consequently, a model of human cerebellar degeneration and ataxia -the Purkinje Cell Degeneration (PCD) mouse- has been employed, as it allows the study of different processes of selective neuronal death in the same animal, i.e., Purkinje cells in the cerebellum and mitral cells in the olfactory bulb. Infiltrated leukocytes were studied in both brain areas and compared with those from other standardized neuroinflammatory models obtained by administerin

SUBMITTER: Del Pilar C 

PROVIDER: S-EPMC8671039 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature