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Advances in chemical proteomic evaluation of lipid kinases-DAG kinases as a case study.

ABSTRACT: Advancements in chemical proteomics and mass spectrometry lipidomics are providing new opportunities to understand lipid kinase activity, specificity, and regulation on a global cellular scale. Here, we describe recent developments in chemical biology of lipid kinases with a focus on those members that phosphorylate diacylglycerols. We further discuss future implications of how these mass spectrometry-based approaches can be adapted for studies of additional lipid kinase members with the aim of bridging the gap between protein and lipid kinase-focused investigations.

SUBMITTER: Ware TB

PROVIDER: S-EPMC8671151 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Advances in chemical proteomic evaluation of lipid kinases-DAG kinases as a case study.

Ware Timothy B TB Hsu Ku-Lung KL

Current opinion in chemical biology 20210723

Advancements in chemical proteomics and mass spectrometry lipidomics are providing new opportunities to understand lipid kinase activity, specificity, and regulation on a global cellular scale. Here, we describe recent developments in chemical biology of lipid kinases with a focus on those members that phosphorylate diacylglycerols. We further discuss future implications of how these mass spectrometry-based approaches can be adapted for studies of additional lipid kinase members with the aim of ...[more]

PMID: 34311404

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