Profiling nonhuman primate germline RNA to understand the legacy of early life stress.

ABSTRACT: Exposure to stress is a risk factor for perturbed mental health, including impoverished regulation of emotional and physiological responses that accompany anxiety and mood disorders, substance abuse and behavioral disorders. Such disruptions to well-being could be triggered by discrete environmental events or pervasive early life stress (ELS) resulting for example from adverse caregiving. Recent data mostly collected from rodents exposed to anthropogenic stressors suggest that one way via which the detrimental effects of such stress extend beyond the exposed population to future offspring is via stress-induced alterations of RNA found in the paternal germline. In contrast, less attention has been paid to how naturally occurring stress in males might influence offspring biology and behavior

SUBMITTER: Morin EL 

PROVIDER: S-EPMC8671153 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature