Oxidative stress implications for therapeutic vaccine development against Chagas disease.

ABSTRACT:

Introduction

Pathogenesis of Chagas disease (CD) caused by the protozoan parasite Trypanosoma cruzi (T. cruzi) involves chronic oxidative and inflammatory stress. In this review, we discuss the research efforts in therapeutic vaccine development to date and the potential challenges imposed by oxidative stress in achieving an efficient therapeutic vaccine against CD.

Areas covered

This review covers the immune and nonimmune mechanisms of reactive oxygen species production and immune response patterns during T. cruzi infection in CD. A discussion on immunotherapy development efforts, the efficacy of antigen-based immune therapies against T. cruzi, and the role of antioxidants as adjuvants is discussed to provide promising insights to developing future trea

SUBMITTER: Choudhuri S 

PROVIDER: S-EPMC8671175 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature