Macroautophagy and aging: The impact of cellular recycling on health and longevity.

ABSTRACT: Aging is associated with many deleterious changes at the cellular level, including the accumulation of potentially toxic components that can have devastating effects on health. A key protective mechanism to this end is the cellular recycling process called autophagy. During autophagy, damaged or surplus cellular components are delivered to acidic vesicles called lysosomes, that secure degradation and recycling of the components. Numerous links between autophagy and aging exist. Autophagy declines with age, and increasing evidence suggests that this reduction plays important roles in both physiological aging and the development of age-associated disorders. Studies in pharmacologically and genetically manipulated model organisms indicate that defects in autophagy promote age-related diseases

SUBMITTER: Nieto-Torres JL 

PROVIDER: S-EPMC8671213 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature