Paclitaxel chemotherapy disrupts behavioral and molecular circadian clocks in mice.

ABSTRACT: Cancer patients experience circadian rhythm disruptions in activity cycles and cortisol release that correlate with poor quality of life and decreased long-term survival rates. However, the extent to which chemotherapy contributes to altered circadian rhythms is poorly understood. In the present study, we examined the extent to which paclitaxel, a common chemotherapy drug, altered entrained and free-running circadian rhythms in wheel running behavior, circulating corticosterone, and circadian clock gene expression in the brain and adrenal glands of tumor-free mice. Paclitaxel injections delayed voluntary wheel running activity onset in a light-dark cycle (LD) and lengthened the free-running period of locomotion in constant darkness (DD), indicating an effect on inherent suprachiasmatic nuc

SUBMITTER: Sullivan KA 

PROVIDER: S-EPMC8671246 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature