Evaluation of heparinized syringes for measuring newborn metabolites in neonates with a central arterial line.

ABSTRACT: Newborn metabolic screening is emerging as a novel method for predicting neonatal morbidity and mortality in neonates born very preterm (<32 weeks gestation). The purpose of our study was to determine if blood collected by an electrolyte-balanced dry lithium heparin syringe, as is routine for blood gas measurements, affects targeted metabolite and biomarker levels. Two blood samples (one collected with a heparinized syringe and the other with a non-heparinized syringe) were obtained at the same time from 20 infants with a central arterial line and tested for 49 metabolites and biomarkers using standard procedures for newborn screening. Overall, the median metabolite levels did not significantly differ by syringe type. However, there was wide variability, particularly for amino acids and im

SUBMITTER: Ryckman KK 

PROVIDER: S-EPMC8671267 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature