The effect of short-term high-caloric feeding and fasting on bone microarchitecture.

ABSTRACT:

Background

States of chronic overnutrition and undernutrition are both associated with impaired bone health and increased fracture risk but there are no data on bone microarchitecture following short-term controlled nutritional challenges.

Objective

The purpose of our study was to evaluate the impact of short-term high-caloric feeding and fasting on bone microarchitecture. We hypothesized that both high-caloric feeding and fasting would have negative effects on microarchitecture.

Materials and methods

We recruited 23 adult healthy subjects (13 males, 10 females, mean age 33.2 ± 1.4 years, mean BMI 26.0 ± 1.5 kg/m²). Subjects underwent an in-patient 10-day high-caloric visit (caloric intake with goal to achieve 7% weight gain), after which they went home to

SUBMITTER: Bredella MA 

PROVIDER: S-EPMC8671292 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature